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Pioglitazone is associated with edema (peripheral, generalized, and pitting edema and fluid retention) when used alone or when used in combination therapy. lapibal mecobalamin 500 mg obat apa In pioglitazone monotherapy trials, edema occurred in 2 5% (n=81), 4 7% (n=275), and 6 5% (n=169) of patients receiving 15 mg, 30 mg, and 45 mg of pioglitazone daily for 16 to 26 weeks